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OCR: e onset of Various endocrine disorders can affect s the onset puberty. Moderate hypothyroidism dela with of puberty and menarche, but treatment rtal thyroxine causes the resumption of pub litus can development. Uncontrolled diabetes me . In its delay puberty and cause irregular mense iac's most severe form this is known as Maur infiltrationsyndrome, which is associated with fatty nd sexual of the liver, short stature, poor growth, a can also infantilism. Untreated Cushing's diseas delay the onset of puberty.